In the beginning, when I first started riding, I hated highway riding - hated it. I felt as though the wind would blow me off the bike, or the wind would blow the bike off the road. I lacked the confidence that I had total control of the motorcycle, and that I could outsmart and outrun the vehicles with whom I was sharing the highway. To me, speed, wind and distance were dangerous.
Time and experience changed my mind with respect to the danger involved, but I still don't really think that highway riding is fun. It's not fun, but it is sometimes very necessary. If you want to get from the Midwest to the east coast, or to the west, and you are not going to trailer your motorcycles, then you're going to have to do some highway riding. You are going to be doing some long distance motorcycle travel . So make the best of it. Look over at those people in cars, and feel sorry for them. You're on a motorcycle!You will encounter drivers who seem to have attitudes against motorcycles. Even if you are wearing a helmet, wearing protective apparel and totally obeying the speed limit, there will be drivers of other vehicles who will show you, in various ways, that they do not like motorcycles, PERIOD. Yes, you will encounter road rage.
You will meet drivers who will drive very, very, very slowly in the right lane, and when you pass them on the left, and then re-enter the right lane, they will speed up, and then drive right behind your rear tail light, honk, and then pass you. Then, once again in the right lane, they will resume the same below-the-speed-limit speed, forcing you to pass them again. (Repeat this sequence until one of the vehicles, 2 or 4 wheeled, needs to exit).
You will meet drivers who believe that they belong in the passing lane, at whatever speed they choose to drive. This means that if you attempt to pass a slower vehicle in the right lane, this "I-belong-in-the-passing-lane" vehicle will speed up, right up to your tail light, honk and force you into the right lane, quickly.
You will meet drivers who don't see you. You will meet drivers who don't want to see you.
You will meet drivers who would really like to be riding a motorcycle, but instead are driving in a vehicle with a spouse or significant other, who will not allow them to be a motorcycle rider.
You will meet drivers who will accelerate and obstruct your entry onto the highway, and drivers who speed up to obstruct your exit from the highway.
There is only one rule to observe when dealing with these highway drivers - IGNORE them. Don't even turn your head to make eye contact. You have the ability to accelerate through any of these situations. Or slow down and let them pass. Either way, do not engage with the drivers who have "issues" with motorcycle riders.
If you are planning to cover a lot of highway miles, it might be a good idea to have a travel guide showing where you can expect to find rest stops.
In my opinion, lane splitting is rarely done safely in the States. I have seen motorcyclists without helmets and protective outerwear, whip through congested highway traffic at high speed, frequently changing lanes. Not recommended - for a variety of reasons.
You might also want to check out some gel palm padded motorcycle gloves for long days of highway riding - end the itch and numbness from vibration.
And, when you arrive at your destination, REST before you start on your adventure.
And have fun!